
Industrialization has undoubtedly improved the quality of life through modern conveniences, technology, and productivity. However, these same advancements have come with hidden costs, particularly to our health. Among the most affected systems is our circadian rhythm, the body’s natural internal clock.
The circadian rhythm is an intrinsic, roughly 24-hour cycle that governs the sleep-wake pattern and numerous physiological processes. It is regulated by the suprachiasmatic nucleus (SCN), a cluster of neurons in the hypothalamus that responds to light signals from the retina. This master clock synchronizes the body with the natural light-dark cycle, influencing hormone release, metabolism, temperature regulation, and even mood.
When this rhythm is disrupted, by irregular sleep schedules, artificial light exposure, late-night eating, or shift work, the effects ripple throughout the body. Such disruptions can lead to sleep disorders, metabolic dysfunction, mood changes, immune dysregulation, and increased stress.

Research on indigenous and pre-industrial populations offers valuable insight into how modern lifestyles alter our biology. These communities typically live in harmony with natural light cycles, waking at sunrise and sleeping shortly after sunset. Their stable routines promote healthy circadian alignment, keeping hormones such as cortisol, melatonin, insulin, and leptin in rhythm, essential for balanced energy, appetite, and emotional well-being.
In contrast, modern societies are bathed in artificial light, especially from screens and indoor lighting during the evening. A study by Wright et al. (2013) found that late-night light exposure disrupts circadian alignment and is linked to reduced insulin sensitivity, increased inflammation, altered hunger cues, and elevated risk for obesity, diabetes, cognitive decline, and mood disorders.

Sleep quality and duration play a central role in metabolic health. A meta-analysis involving over 300,000 participants (Che et al., 2021) found that both short (<6 hours) and long (>9 hours) sleep durations were associated with an increased risk of metabolic syndrome, a cluster of conditions including obesity, hypertension, elevated triglycerides, low HDL cholesterol, and impaired glucose control. Interestingly, this association was less significant in adults over age 65.
The mechanisms behind this relationship are complex. Poor sleep leads to an imbalance in the autonomic nervous system, with reduced parasympathetic (rest-and-digest) activity and heightened sympathetic (fight-or-flight) tone. This imbalance increases heart rate, blood pressure, insulin resistance, and digestive dysfunction. Elevated cortisol further promotes fat deposition and metabolic stress. Meanwhile, sleep deprivation alters the hunger hormones ghrelin and leptin, encouraging overeating and cravings for high-calorie foods.
On an inflammatory level, sleep loss increases pro-inflammatory cytokines such as IL-6, TNF-α, and CRP, driving chronic low-grade inflammation that underlies obesity, cardiovascular disease, and autoimmune conditions.
Inflammation doesn’t just affect the body, it also impacts the brain. Pro-inflammatory cytokines can cross the blood-brain barrier, triggering neuroinflammation. During deep sleep, the glymphatic system clears out metabolic waste, including amyloid-beta and tau proteins, which are implicated in Alzheimer’s disease. When sleep is disrupted, this cleansing process is impaired, leading to toxic accumulation.

Sleep also supports synaptic pruning, neurotransmitter balance, and neuroplasticity, processes essential for memory consolidation and emotional regulation. Chronic sleep deprivation reduces levels of brain-derived neurotrophic factor (BDNF), which impairs learning, memory, and resilience to stress. Over time, metabolic and inflammatory stress contribute to cerebrovascular damage, white matter changes, and increased risk of cognitive decline.
Prioritize light exposure – Get morning sunlight for at least 15–30 minutes to reinforce your circadian rhythm.
Limit blue light at night – Dim indoor lighting after sunset, avoid screens 1–2 hours before bed, or use blue-light–blocking glasses.
Maintain consistent sleep and wake times, even on weekends.
Avoid eating late at night – Finish your last meal at least 2–3 hours before bedtime to prevent metabolic disruption.
Create a relaxing bedtime routine – Try gentle stretching, meditation, or reading a physical book.
Keep your bedroom cool, dark, and quiet – Around 65–68°F is optimal for most people.
Limit caffeine and alcohol, especially in the afternoon and evening.
Incorporate regular movement – Physical activity during the day helps improve sleep quality, but avoid vigorous exercise right before bed.
Industrialization and technology have changed nearly every aspect of modern life, including how we sleep. Yet, our biology remains deeply tied to natural rhythms. Reconnecting with these cycles through consistent sleep habits, mindful light exposure, and reduced nighttime stimulation can restore not only restful sleep but also metabolic, emotional, and cognitive health.
Protecting your circadian rhythm may be one of the most powerful, and accessible, steps toward lifelong wellness.
Wright, K. P., Jr, McHill, A. W., Birks, B. R., Griffin, B. R., Rusterholz, T., & Chinoy, E. D. (2013). Entrainment of the human circadian clock to the natural light-dark cycle. Current biology : CB, 23(16), 1554–1558. https://doi.org/10.1016/j.cub.2013.06.039
Smit, A. N., Broesch, T., Siegel, J. M., & Mistlberger, R. E. (2019). Sleep timing and duration in indigenous villages with and without electric lighting on Tanna Island, Vanuatu. Scientific reports, 9(1), 17278. https://doi.org/10.1038/s41598-019-53635-y
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009). Effects of poor and short sleep on glucose metabolism and obesity risk. Nature reviews. Endocrinology, 5(5), 253–261. https://doi.org/10.1038/nrendo.2009.23
Knutson, Xu, W., Tan, C. C., Zou, J. J., Cao, X. P., & Tan, L. (2020). Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis. Journal of neurology, neurosurgery, and psychiatry, 91(3), 236–244. https://doi.org/10.1136/jnnp-2019-321896
K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007). The metabolic consequences of sleep deprivation. Sleep medicine reviews, 11(3), 163–178. https://doi.org/10.1016/j.smrv.2007.01.002
Che, T., Yan, C., Tian, D., Zhang, X., Liu, X., & Wu, Z. (2021). The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis. Frontiers in endocrinology, 12, 773646. https://doi.org/10.3389/fendo.2021.773646
Khan, M. A., & Al-Jahdali, H. (2023). The consequences of sleep deprivation on cognitive performance. Neurosciences (Riyadh, Saudi Arabia), 28(2), 91–99. https://doi.org/10.17712/nsj.2023.2.20220108
Xu, W., Tan, C. C., Zou, J. J., Cao, X. P., & Tan, L. (2020). Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis. Journal of neurology, neurosurgery, and psychiatry, 91(3), 236–244. https://doi.org/10.1136/jnnp-2019-321896
Latest Blog Posts
